Sunday 10 April 2011

Q5

Q5.  A 16 year old girl is brought by her mother to her physician. Her mother complains that her daughter has a poor sexual physical development, has primary ammenhorrhea and is too short. On inspection the girl appears withdrawn and abrupt. She appears rather pale and thin and has fine coat of hair all over her body. Her parotid glands appear to be enlarged. On investigation the levels of plasma FSH and LH are low. The most likely diagnosis is 
a) constitutional delay
b) hypothyroidism
c) anorexia nervosa
d) Kallmann's syndrome
e) ovarian dysgenesis
answer and explanation:
Answer : "C"
Explanation:
It is not uncommon for patients with anorexia nervosa to be referred months after the onset; growth failure may be the first sign, and this condition must be considered in the differential diagnosis of growth failure. Anorexia nervosa, a common cause of gonadotropin deficiency in adolescence, is a functional disorder, apparently increasing in prevalence in girls but rare in boys, and is characterized by a distorted body image, obsessive fear of obesity, and food avoidance that can cause severe weight loss, primary or secondary amenorrhea in affected females, and even death. Other features include onset in middle adolescence, hyperactivity, defective thermoregulation with hypothermia and sensitivity to cold, constipation, bradycardia and hypotension, decreased basal metabolic rate, dry skin, fine downy hypertrichosis, peripheral edema, and parotid enlargement. In anorexia nervosa the levels of plasma FSH, LH, leptin, and estradiol and of urinary gonadotropins are low.

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